The Protein Prediction Showdown: RosettaFold All Atom vs. AlphaFold - Breaking Boundaries in Protein Structure Prediction

A new protein structure prediction model released by David Baker’s laboratory is making waves in the scientific community, challenging the dominance of DeepMind’s AlphaFold. The model, named RosettaFold All Atom, not only predicts protein structures but also incorporates bound DNA and ligands. What sets this model apart is its open-source nature, allowing for greater accessibility and collaboration within the scientific community.


The rivalry between DeepMind’s AlphaFold and Baker’s laboratory model adds an exciting dynamic to the field of protein structure prediction. Baker, who is credited with extending AlphaFold’s capabilities to include predicting ligands, continues to push the boundaries of what is possible in this field.

One key feature of the RosettaFold paper that is generating excitement is the utilization of the structure predicting model as a denoising mechanism in a diffusion process, enabling the design of new functional proteins. This innovative approach hints at the potential for further advancements in protein engineering and drug development.

However, amid the buzz surrounding these advancements, questions have been raised about the accuracy of these models and the implications of their use. While DeepMind’s AlphaFold has been lauded for its capabilities in predicting protein structures, concerns have been raised about its efficacy in predicting novel patterns and structures.

The decision to keep the technology closed-source has also sparked debate within the scientific community. Critics argue that making such powerful tools available only to a select few limits the potential for collaborative research and progress within the field.

Overall, the emergence of the RosettaFold All Atom model signals a new chapter in the ongoing quest to unlock the mysteries of protein structure prediction. As researchers continue to refine these models and explore new applications, the future of drug development and disease research holds promising possibilities.

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